We list 14 methadone clinics in Missouri, based on SAMHSA's FindTreatment.gov data, with the most in Kansas City (3), Saint Louis (3), and West Plains (1). Compare services, insurance accepted and accreditation, or call for free help choosing.
Methadone Clinic (OTP): the basics
A methadone clinic, formally called an opioid treatment program (OTP), is a federally certified clinic that treats opioid use disorder with medication, mainly methadone. You visit to take a supervised dose and get counseling and medical care. Under 2024 federal rules, stable patients can earn take-home doses sooner. Search below to find methadone clinics near you. Read the full guide →
2026 rankings
Ranked by the StartDrugRehab Score: accreditation, levels of care, patient ratings and payment options. Featured or claimed status never affects rank. How we rank
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, PHP, IOP, and outpatient care; accepts private insurance, Medicaid, and self-pay.
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, IOP, outpatient care, and MAT; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, IOP, outpatient care, and MAT; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxJoint Commission
Why it made our list: Joint Commission accredited; offers detox, outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, IOP, outpatient care, and MAT; accepts private insurance, Medicaid, and Medicare.
Best for: Methadone treatmentJoint Commission
Why it made our list: Joint Commission accredited; offers IOP, outpatient care, and MAT; accepts private insurance, Medicaid, and Medicare.
Best for: Methadone treatmentJoint CommissionCARF
Why it made our list: Joint Commission and CARF accredited; offers outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxJoint Commission
Why it made our list: Joint Commission accredited; offers detox, outpatient care, and MAT; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, IOP, outpatient care, and MAT; accepts private insurance, Medicaid, and Medicare.
Best for: Methadone treatmentJoint CommissionCARF
Why it made our list: Joint Commission and CARF accredited; offers outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
West Plains, MO 65775
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Saint Charles, MO 63301
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Saint Joseph, MO 64506
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Saint Louis, MO 63120
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
Poplar Bluff, MO 63901
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Cape Girardeau, MO 63703
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +1 more
“Get help” calls our free helpline, not this facility.
Kansas City, MO 64108
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · TRICARE +3 more
“Get help” calls our free helpline, not this facility.
Kansas City, MO 64134
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · TRICARE +3 more
“Get help” calls our free helpline, not this facility.
Saint Louis, MO 63114
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +1 more
“Get help” calls our free helpline, not this facility.
Saint Louis, MO 63106
Joint Commission accredited
Levels of care
Payment accepted
TRICARE
“Get help” calls our free helpline, not this facility.
Columbia, MO 65202
Joint Commission · CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +4 more
“Get help” calls our free helpline, not this facility.
Joplin, MO 64801
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Kansas City, MO 64108
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Sedalia, MO 65301
Joint Commission · CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +4 more
“Get help” calls our free helpline, not this facility.
We list 14 methadone clinics in Missouri, based on SAMHSA's FindTreatment.gov data (updated October 2026).
The most listings are in Kansas City (3), Saint Louis (3), and West Plains (1).
Look for state licensing and accreditation (The Joint Commission or CARF), the right level of care for your needs, evidence-based therapies, and insurance compatibility. Read our guide to choosing a rehab or call (833) 589-6933 to talk it through.
Most private plans and Medicaid cover substance use treatment when it's medically necessary, but benefits vary by plan and network. Call (833) 589-6933 for a free, confidential benefits check.
Source: SAMHSA FindTreatment.gov, data updated October 2026. Listings are not endorsements.
