We list 214 mat programs in Missouri, based on SAMHSA's FindTreatment.gov data, with the most in Saint Louis (18), Kansas City (15), and Springfield (9). Compare services, insurance accepted and accreditation, or call for free help choosing.
Medication-Assisted Treatment (MAT): the basics
Medication-assisted treatment (MAT) uses FDA-approved medications, usually alongside counseling, to treat opioid and alcohol use disorders. For opioids, the options are buprenorphine (including Suboxone), methadone and naltrexone. These medications ease cravings and withdrawal, help prevent a return to use and lower overdose risk. Search below to find MAT and Suboxone clinics near you. Read the full guide →
2026 rankings
Ranked by the StartDrugRehab Score: accreditation, levels of care, patient ratings and payment options. Featured or claimed status never affects rank. How we rank
Best for: Residential treatmentJoint CommissionCARF
Why it made our list: Joint Commission, CARF, COA, and NCQA accredited; offers residential care, PHP, IOP, and outpatient care; accepts private insurance, Medicaid, and Medicare.
Best for: Detox and residential careCARF
Why it made our list: CARF accredited; offers detox, residential care, PHP, and IOP; accepts private insurance, TRICARE, and self-pay.
Best for: Residential treatmentJoint CommissionCARF
Why it made our list: Joint Commission and CARF accredited; offers residential care, PHP, IOP, and outpatient care; accepts private insurance, Medicaid, and Medicare.
Best for: Detox and residential careCARF
Why it made our list: CARF accredited; offers detox, residential care, PHP, and IOP; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, PHP, IOP, and outpatient care; accepts private insurance, Medicaid, and Medicare.
Best for: Private-pay residential careCARF
Why it made our list: CARF accredited; offers detox, residential care, PHP, and IOP; accepts private insurance, TRICARE, and self-pay.
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, PHP, IOP, and outpatient care; accepts private insurance, Medicaid, and self-pay.
Best for: Detox and residential careCARF
Why it made our list: CARF accredited; offers detox, residential care, PHP, and IOP; accepts private insurance, Medicaid, and Medicare.
Best for: Private-pay residential careJoint Commission
Why it made our list: Joint Commission accredited; offers detox, residential care, PHP, and MAT; accepts private insurance, TRICARE, and self-pay.
Best for: Residential treatmentCARF
Why it made our list: CARF accredited; offers residential care, IOP, outpatient care, and MAT; accepts private insurance, Medicaid, and Medicare.
Eolia, MO 63344
CARF accredited
Levels of care
Payment accepted
Private insurance · TRICARE · Self-pay
“Get help” calls our free helpline, not this facility.
Saint Louis, MO 63116
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Kirksville, MO 63501
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +4 more
“Get help” calls our free helpline, not this facility.
Saint Charles, MO 63303
CARF accredited
Levels of care
Payment accepted
Private insurance · TRICARE · Self-pay
“Get help” calls our free helpline, not this facility.
Farmington, MO 63640
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +4 more
“Get help” calls our free helpline, not this facility.
Hannibal, MO 63401
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
Dittmer, MO 63023
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · TRICARE · Self-pay
“Get help” calls our free helpline, not this facility.
Boonville, MO 65233
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · TRICARE · Self-pay
“Get help” calls our free helpline, not this facility.
Saint Louis, MO 63103
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
Saint Louis, MO 63136
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
Marshall, MO 65340
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · Self-pay
“Get help” calls our free helpline, not this facility.
Poplar Bluff, MO 63901
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +4 more
“Get help” calls our free helpline, not this facility.
Salem, MO 65560
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +4 more
“Get help” calls our free helpline, not this facility.
Joint Commission · CARF · COA · NCQA accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Columbia, MO 65201
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +1 more
“Get help” calls our free helpline, not this facility.
Joplin, MO 64804
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +4 more
“Get help” calls our free helpline, not this facility.
Saint Louis, MO 63108
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Rogersville, MO 65742
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · Self-pay
“Get help” calls our free helpline, not this facility.
West Plains, MO 65775
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Saint Louis, MO 63118
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Saint Charles, MO 63303
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Jefferson City, MO 65101
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +4 more
“Get help” calls our free helpline, not this facility.
Trenton, MO 64683
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Kansas City, MO 64133
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +4 more
“Get help” calls our free helpline, not this facility.
Columbia, MO 65202
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Kansas City, MO 64131
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Independence, MO 64055
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Harrisonville, MO 64701
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Nevada, MO 64772
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Columbia, MO 65203
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
We list 214 mat programs in Missouri, based on SAMHSA's FindTreatment.gov data (updated October 2026).
The most listings are in Saint Louis (18), Kansas City (15), and Springfield (9).
Look for state licensing and accreditation (The Joint Commission or CARF), the right level of care for your needs, evidence-based therapies, and insurance compatibility. Read our guide to choosing a rehab or call (833) 589-6933 to talk it through.
Most private plans and Medicaid cover substance use treatment when it's medically necessary, but benefits vary by plan and network. Call (833) 589-6933 for a free, confidential benefits check.
Source: SAMHSA FindTreatment.gov, data updated October 2026. Listings are not endorsements.
