We list 20 mat programs in South Dakota, based on SAMHSA's FindTreatment.gov data, with the most in Rapid City (4), Sioux Falls (2), and Madison (2). Compare services, insurance accepted and accreditation, or call for free help choosing.
Medication-Assisted Treatment (MAT): the basics
Medication-assisted treatment (MAT) uses FDA-approved medications, usually alongside counseling, to treat opioid and alcohol use disorders. For opioids, the options are buprenorphine (including Suboxone), methadone and naltrexone. These medications ease cravings and withdrawal, help prevent a return to use and lower overdose risk. Search below to find MAT and Suboxone clinics near you. Read the full guide →
2026 rankings
Ranked by the StartDrugRehab Score: accreditation, levels of care, patient ratings and payment options. Featured or claimed status never affects rank. How we rank
Best for: Detox and residential careJoint Commission
Why it made our list: Joint Commission accredited; offers detox, residential care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Detox and residential careCARF
Why it made our list: CARF accredited; offers detox, residential care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Detox and residential careCARF
Why it made our list: CARF accredited; offers detox, residential care, IOP, and MAT; accepts private insurance, Medicaid, and self-pay.
Best for: Veterans (VA care)Joint Commission
Why it made our list: Joint Commission accredited; offers residential care, outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Veterans (VA care)Joint Commission
Why it made our list: Joint Commission accredited; offers outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Detox and residential care
Why it made our list: Offers detox, residential care, PHP, and IOP; accepts private insurance, Medicaid, and Medicare.
Best for: Methadone treatmentCARF
Why it made our list: CARF accredited; offers outpatient care and MAT; accepts private insurance, Medicaid, and Medicare.
Best for: Outpatient care with MATJoint Commission
Why it made our list: Joint Commission accredited; offers outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Residential treatmentJoint Commission
Why it made our list: Joint Commission accredited; offers residential care, MAT, and dual diagnosis care; accepts Medicaid.
Best for: Detox and residential care
Why it made our list: Offers detox, residential care, IOP, and outpatient care; accepts private insurance, Medicaid, and Medicare.
Rapid City, SD 57701
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Howard, SD 57349
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay
“Get help” calls our free helpline, not this facility.
Canton, SD 57013
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Yankton, SD 57078
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Madison, SD 57042
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +1 more
“Get help” calls our free helpline, not this facility.
Hot Springs, SD 57747
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +1 more
“Get help” calls our free helpline, not this facility.
Rapid City, SD 57701
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Mobridge, SD 57601
Joint Commission accredited
Levels of care
Payment accepted
Medicaid
“Get help” calls our free helpline, not this facility.
Sioux Falls, SD 57104
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Rapid City, SD 57701
Levels of care
Payment accepted
Medicaid · Self-pay · State-funded
“Get help” calls our free helpline, not this facility.
Rapid City, SD 57701
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +1 more
“Get help” calls our free helpline, not this facility.
Fort Meade, SD 57741
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +1 more
“Get help” calls our free helpline, not this facility.
Sioux Falls, SD 57105
COA accredited
Levels of care
Payment accepted
Medicaid · Private insurance · TRICARE +3 more
“Get help” calls our free helpline, not this facility.
Levels of care
Payment accepted
Medicaid · Private insurance · TRICARE +1 more
“Get help” calls our free helpline, not this facility.
Levels of care
Payment accepted
Self-pay
“Get help” calls our free helpline, not this facility.
Pierre, SD 57501
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Huron, SD 57350
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +2 more
“Get help” calls our free helpline, not this facility.
Madison, SD 57042
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +2 more
“Get help” calls our free helpline, not this facility.
Flandreau, SD 57028
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Fort Thompson, SD 57339
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +1 more
“Get help” calls our free helpline, not this facility.
We list 20 mat programs in South Dakota, based on SAMHSA's FindTreatment.gov data (updated October 2026).
The most listings are in Rapid City (4), Sioux Falls (2), and Madison (2).
Look for state licensing and accreditation (The Joint Commission or CARF), the right level of care for your needs, evidence-based therapies, and insurance compatibility. Read our guide to choosing a rehab or call (833) 589-6933 to talk it through.
Most private plans and Medicaid cover substance use treatment when it's medically necessary, but benefits vary by plan and network. Call (833) 589-6933 for a free, confidential benefits check.
Source: SAMHSA FindTreatment.gov, data updated October 2026. Listings are not endorsements.
