We list 80 mat programs in South Carolina, based on SAMHSA's FindTreatment.gov data, with the most in Greenville (8), Florence (6), and Columbia (5). Compare services, insurance accepted and accreditation, or call for free help choosing.
Medication-Assisted Treatment (MAT): the basics
Medication-assisted treatment (MAT) uses FDA-approved medications, usually alongside counseling, to treat opioid and alcohol use disorders. For opioids, the options are buprenorphine (including Suboxone), methadone and naltrexone. These medications ease cravings and withdrawal, help prevent a return to use and lower overdose risk. Search below to find MAT and Suboxone clinics near you. Read the full guide →
2026 rankings
Ranked by the StartDrugRehab Score: accreditation, levels of care, patient ratings and payment options. Featured or claimed status never affects rank. How we rank
Best for: Private-pay residential careJoint CommissionCOA
Why it made our list: Joint Commission and COA accredited; offers detox, residential care, PHP, and IOP; accepts private insurance and self-pay.
Best for: Supervised detoxJoint Commission
Why it made our list: Joint Commission accredited; offers detox, PHP, IOP, and outpatient care; accepts private insurance, TRICARE, and self-pay.
Best for: Supervised detoxJoint Commission
Why it made our list: Joint Commission accredited; offers detox, outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxJoint Commission
Why it made our list: Joint Commission accredited; offers detox, PHP, IOP, and outpatient care; accepts private insurance and self-pay.
Best for: Residential treatmentCARF
Why it made our list: CARF accredited; offers residential care, PHP, IOP, and outpatient care; accepts private insurance, Medicaid, and TRICARE.
Best for: Supervised detoxJoint Commission
Why it made our list: Joint Commission accredited; offers detox, PHP, IOP, and MAT; accepts private insurance, Medicare, and TRICARE.
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Intensive outpatient careJoint Commission
Why it made our list: Joint Commission accredited; offers PHP, IOP, MAT, and dual diagnosis care; accepts private insurance, TRICARE, and self-pay.
Best for: Intensive outpatient careJoint Commission
Why it made our list: Joint Commission accredited; offers PHP, IOP, outpatient care, and MAT; accepts private insurance, TRICARE, and self-pay.
Best for: Supervised detoxJoint Commission
Why it made our list: Joint Commission accredited; offers detox, outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Rock Hill, SC 29732
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +2 more
“Get help” calls our free helpline, not this facility.
Columbia, SC 29203
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Greenville, SC 29615
Joint Commission · COA accredited
Levels of care
Payment accepted
Private insurance · Self-pay
“Get help” calls our free helpline, not this facility.
Chesnee, SC 29323
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · TRICARE · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
North Charleston, SC 29405
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Columbia, SC 29203
CARF accredited
Levels of care
Payment accepted
Private insurance · TRICARE · Self-pay
“Get help” calls our free helpline, not this facility.
Simpsonville, SC 29680
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Aiken, SC 29801
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
North Charleston, SC 29405
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Greer, SC 29650
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Myrtle Beach, SC 29577
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · Self-pay
“Get help” calls our free helpline, not this facility.
Greenville, SC 29607
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · TRICARE +3 more
“Get help” calls our free helpline, not this facility.
Greenville, SC 29611
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · TRICARE +3 more
“Get help” calls our free helpline, not this facility.
Bluffton, SC 29910
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · TRICARE · Self-pay
“Get help” calls our free helpline, not this facility.
Florence, SC 29501
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
West Columbia, SC 29169
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · TRICARE +2 more
“Get help” calls our free helpline, not this facility.
Spartanburg, SC 29307
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
Myrtle Beach, SC 29577
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Columbia, SC 29210
Joint Commission accredited
Levels of care
Payment accepted
Medicare · Private insurance · TRICARE +1 more
“Get help” calls our free helpline, not this facility.
Orangeburg, SC 29115
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Private insurance · TRICARE +3 more
“Get help” calls our free helpline, not this facility.
Jacksonboro, SC 29452
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · Self-pay
“Get help” calls our free helpline, not this facility.
Florence, SC 29501
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · TRICARE · Self-pay
“Get help” calls our free helpline, not this facility.
North Charleston, SC 29405
Joint Commission accredited
Levels of care
Payment accepted
Private insurance · TRICARE · Self-pay +2 more
“Get help” calls our free helpline, not this facility.
Aiken, SC 29801
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +2 more
“Get help” calls our free helpline, not this facility.
Chesterfield, SC 29709
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +2 more
“Get help” calls our free helpline, not this facility.
Camden, SC 29020
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +2 more
“Get help” calls our free helpline, not this facility.
Barnwell, SC 29812
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
Easley, SC 29640
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · TRICARE +3 more
“Get help” calls our free helpline, not this facility.
Aiken, SC 29801
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Spartanburg, SC 29303
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
We list 80 mat programs in South Carolina, based on SAMHSA's FindTreatment.gov data (updated October 2026).
The most listings are in Greenville (8), Florence (6), and Columbia (5).
Look for state licensing and accreditation (The Joint Commission or CARF), the right level of care for your needs, evidence-based therapies, and insurance compatibility. Read our guide to choosing a rehab or call (833) 589-6933 to talk it through.
Most private plans and Medicaid cover substance use treatment when it's medically necessary, but benefits vary by plan and network. Call (833) 589-6933 for a free, confidential benefits check.
Source: SAMHSA FindTreatment.gov, data updated October 2026. Listings are not endorsements.
