We list 26 methadone clinics in South Carolina, based on SAMHSA's FindTreatment.gov data, with the most in Greenville (2), West Columbia (2), and Florence (2). Compare services, insurance accepted and accreditation, or call for free help choosing.
Methadone Clinic (OTP): the basics
A methadone clinic, formally called an opioid treatment program (OTP), is a federally certified clinic that treats opioid use disorder with medication, mainly methadone. You visit to take a supervised dose and get counseling and medical care. Under 2024 federal rules, stable patients can earn take-home doses sooner. Search below to find methadone clinics near you. Read the full guide →
2026 rankings
Ranked by the StartDrugRehab Score: accreditation, levels of care, patient ratings and payment options. Featured or claimed status never affects rank. How we rank
Best for: Supervised detoxJoint Commission
Why it made our list: Joint Commission accredited; offers detox, outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxJoint Commission
Why it made our list: Joint Commission accredited; offers detox, outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Methadone treatmentCARF
Why it made our list: CARF accredited; offers outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Methadone treatmentCARF
Why it made our list: CARF accredited; offers outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Supervised detoxCARF
Why it made our list: CARF accredited; offers detox, IOP, outpatient care, and MAT; accepts Medicaid, Medicare, and TRICARE.
Best for: Methadone treatmentCARF
Why it made our list: CARF accredited; offers MAT and dual diagnosis care; accepts private insurance, Medicaid, and Medicare.
Best for: Detox and residential careCARF
Why it made our list: CARF accredited; offers detox, residential care, IOP, and outpatient care; accepts private insurance, Medicaid, and Medicare.
Best for: Methadone treatmentJoint Commission
Why it made our list: Joint Commission accredited; offers outpatient care and MAT; accepts private insurance, Medicaid, and Medicare.
Best for: Methadone treatmentCARF
Why it made our list: CARF accredited; offers outpatient care, MAT, and dual diagnosis care; accepts private insurance, Medicaid, and self-pay.
North Charleston, SC 29405
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Simpsonville, SC 29680
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
North Charleston, SC 29405
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
West Columbia, SC 29169
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · TRICARE +2 more
“Get help” calls our free helpline, not this facility.
Myrtle Beach, SC 29577
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Aiken, SC 29801
Joint Commission accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Florence, SC 29505
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Georgetown, SC 29440
CARF accredited
Levels of care
Payment accepted
Medicaid · Private insurance · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
Greenville, SC 29607
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Sumter, SC 29150
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Fort Mill, SC 29708
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Myrtle Beach, SC 29579
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Clinton, SC 29325
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Self-pay
“Get help” calls our free helpline, not this facility.
Columbia, SC 29201
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Charleston, SC 29406
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Greenville, SC 29615
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Seneca, SC 29678
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Easley, SC 29640
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Self-pay +1 more
“Get help” calls our free helpline, not this facility.
Greenwood, SC 29646
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Lancaster, SC 29720
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
West Columbia, SC 29169
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +3 more
“Get help” calls our free helpline, not this facility.
Duncan, SC 29334
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Rock Hill, SC 29730
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Anderson, SC 29625
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +1 more
“Get help” calls our free helpline, not this facility.
Hartsville, SC 29550
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
Florence, SC 29501
CARF accredited
Levels of care
Payment accepted
Medicaid · Medicare · Private insurance +2 more
“Get help” calls our free helpline, not this facility.
We list 26 methadone clinics in South Carolina, based on SAMHSA's FindTreatment.gov data (updated October 2026).
The most listings are in Greenville (2), West Columbia (2), and Florence (2).
Look for state licensing and accreditation (The Joint Commission or CARF), the right level of care for your needs, evidence-based therapies, and insurance compatibility. Read our guide to choosing a rehab or call (833) 589-6933 to talk it through.
Most private plans and Medicaid cover substance use treatment when it's medically necessary, but benefits vary by plan and network. Call (833) 589-6933 for a free, confidential benefits check.
Source: SAMHSA FindTreatment.gov, data updated October 2026. Listings are not endorsements.
