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Greenville, South Carolina · 8 licensed programs

6 Best Rehab Centers in Greenville, SC (2026)

Greenville, SC has 8 licensed drug and alcohol treatment facilities listed in SAMHSA's FindTreatment.gov data: 3 offer detox, 3 provide residential (inpatient) care, 8 offer medication-assisted treatment, and 5 accept Healthy Connections (SC Medicaid). Compare levels of care, insurance accepted and accreditation below.

  • 8Treatment facilities
  • 3Offer detox
  • 3Inpatient / residential
  • 5Accept Medicaid

2026 rankings

Top 6 rehab centers in Greenville, SC

Ranked by the StartDrugRehab Score: accreditation, levels of care, patient ratings and payment options. Featured or claimed status never affects rank. How we rank

  1. Recovery Centers of America

    Greenville, SC

    8.8ExcellentStartDrugRehab Score 8.8 out of 10
    4.7Google276 reviews

    Best for: Private-pay residential careJoint CommissionCOA

    Why it made our list: Joint Commission and COA accredited; offers detox, residential care, PHP, and IOP; accepts private insurance and self-pay.

    View details
  2. Phoenix Center – Serenity Place/Womens Residential

    Greenville, SC

    8.3ExcellentStartDrugRehab Score 8.3 out of 10
    4.1Google9 reviews

    Best for: Residential treatmentCARF

    Why it made our list: CARF accredited; offers residential care, PHP, IOP, and outpatient care; accepts private insurance, Medicaid, and TRICARE.

    View details
  3. Pavillon – Greenville Outpatient Services

    Greenville, SC

    7.5Very goodStartDrugRehab Score 7.5 out of 10

    Best for: Intensive outpatient careCARF

    Why it made our list: CARF accredited; offers IOP, outpatient care, MAT, and dual diagnosis care; accepts private insurance and self-pay.

    View details
  4. Crossroads Treatment Centers – Greenville PC

    Greenville, SC

    6.9GoodStartDrugRehab Score 6.9 out of 10
    4.1Google56 reviews

    Best for: Methadone treatmentCARF

    Why it made our list: CARF accredited; offers MAT; accepts private insurance, Medicaid, and Medicare.

    View details
  5. Greenville Metro Treatment Center – Metro Treatment of South Carolina LP

    Greenville, SC

    6.6GoodStartDrugRehab Score 6.6 out of 10
    3.1Google46 reviews

    Best for: Methadone treatmentCARF

    Why it made our list: CARF accredited; offers IOP and MAT; accepts private insurance, Medicaid, and Medicare.

    View details
  6. Life Line Services LLC

    Greenville, SC

    6.3GoodStartDrugRehab Score 6.3 out of 10

    Best for: Supervised detox

    Why it made our list: Offers detox, outpatient care, MAT, and dual diagnosis care; accepts private insurance and self-pay.

    View details

See the best rehab centers in South Carolina →

All treatment centers in Greenville

Recovery Centers of America

Greenville, SC 29615

8.8ExcellentStartDrugRehab Score 8.8 out of 10
4.7Google276 reviews

Joint Commission · COA accredited

Setting
In/Outpatient
Operator
Private
MAT
Offered

Levels of care

  • Detox
  • Inpatient / Residential
  • Hospital Inpatient
  • +5 more

Payment accepted

Private insurance · Self-pay

“Get help” calls our free helpline, not this facility.

7.4Very goodStartDrugRehab Score 7.4 out of 10

CARF accredited

Setting
Inpatient
Operator
Public
MAT
Offered

Levels of care

  • Detox
  • Inpatient / Residential
  • Medication-Assisted Treatment

Payment accepted

Medicaid · Private insurance · TRICARE +3 more

“Get help” calls our free helpline, not this facility.

8.3ExcellentStartDrugRehab Score 8.3 out of 10
4.1Google9 reviews

CARF accredited

Setting
In/Outpatient
Operator
Public
MAT
Offered

Levels of care

  • Inpatient / Residential
  • Partial Hospitalization
  • Intensive Outpatient
  • +4 more

Payment accepted

Medicaid · Private insurance · TRICARE +3 more

“Get help” calls our free helpline, not this facility.

7.5Very goodStartDrugRehab Score 7.5 out of 10

CARF accredited

Setting
Outpatient
Operator
Nonprofit
MAT
Offered

Levels of care

  • Intensive Outpatient
  • Outpatient
  • Medication-Assisted Treatment
  • +2 more

Payment accepted

Private insurance · Self-pay

“Get help” calls our free helpline, not this facility.

7.2Very goodStartDrugRehab Score 7.2 out of 10
3.3Google105 reviews

CARF accredited

Setting
Outpatient
Operator
Public
MAT
Offered

Levels of care

  • Intensive Outpatient
  • Outpatient
  • Medication-Assisted Treatment
  • +1 more

Payment accepted

Medicaid · Private insurance · TRICARE +3 more

“Get help” calls our free helpline, not this facility.

6.9GoodStartDrugRehab Score 6.9 out of 10
4.1Google56 reviews

CARF accredited

Setting
Outpatient
Operator
Private
MAT
Offered

Levels of care

  • Medication-Assisted Treatment
  • Methadone Clinic
  • Telehealth

Payment accepted

Medicaid · Medicare · Private insurance +2 more

“Get help” calls our free helpline, not this facility.

Life Line Services LLC

Greenville, SC 29605

6.3GoodStartDrugRehab Score 6.3 out of 10
Setting
In/Outpatient
Operator
Private
MAT
Offered

Levels of care

  • Detox
  • Outpatient
  • Medication-Assisted Treatment
  • +2 more

Payment accepted

Private insurance · Self-pay

“Get help” calls our free helpline, not this facility.

Levels of care available in Greenville

Level of careFacilities in GreenvilleStatewide
Detox3 in Greenville18 in SC
Inpatient / Residential3 in Greenville15 in SC
Hospital Inpatient18 in SC
Partial Hospitalization (PHP)210 in SC
Intensive Outpatient (IOP)5 in Greenville36 in SC
Outpatient5 in Greenville66 in SC
Medication-Assisted Treatment (MAT)8 in Greenville80 in SC
Methadone Clinic (OTP)226 in SC
Dual Diagnosis4 in Greenville70 in SC
Sober Living / Transitional Housing16 in Greenville139 in SC
Telehealth5 in Greenville72 in SC
Mental Health Treatment14 in SC

By insurance in Greenville

Programs for specific groups

Rehab near Greenville

All rehab centers in South Carolina →

Frequently asked questions

How many drug and alcohol rehab centers are in Greenville, SC?

Our directory lists 8 licensed substance use treatment facilities in Greenville, SC, based on SAMHSA's FindTreatment.gov data (updated October 2026). Listings include outpatient, residential, detox and medication-assisted treatment programs.

Are there detox centers in Greenville, SC?

Yes. 3 programs in Greenville, SC offer detoxification (medically supervised withdrawal) services. Alcohol and benzodiazepine withdrawal can be dangerous, so medical supervision is strongly recommended.

Which rehabs in Greenville, SC accept Healthy Connections (SC Medicaid)?

5 facilities in Greenville, SC report accepting Medicaid (Healthy Connections (SC Medicaid)). Coverage depends on your plan and the program's network, so confirm before admission.

Do rehabs in Greenville, SC take private insurance?

8 facilities in Greenville, SC accept private health insurance. Benefits vary by plan (deductibles, prior authorization, in- vs. out-of-network). Call (833) 589-6933 for a free insurance check.

Is there inpatient rehab in Greenville, SC?

3 facilities in Greenville, SC offer residential (inpatient) treatment, where you live on site 24/7 while in care. Learn more about inpatient rehab.

Can I get medication-assisted treatment (MAT) in Greenville, SC?

Yes. 8 programs in Greenville, SC use FDA-approved medications such as buprenorphine, naltrexone or methadone. See our guide to MAT.

Source: SAMHSA FindTreatment.gov, data updated October 2026. Listings are not endorsements.